CBD (short for Cannabidiol) is one of over 100 compounds called cannabinoids that are found in cannabis plants. Cannabis plants contain both CBD and THC (tetrahydrocannabinol) which is another cannabinoid. CBD provides all the medical benefits of cannabis while THC produces the mind-altering effects that marijuana is known for. Since CBD does not cause psychoactive effects, it is an excellent option for people seeking the benefits of cannabis products without getting high or breaking federal law.
The benefits of CBD were first discovered in the 1940's but due to the legal status and social stigma of cannabis at the time, it wasn't widely accepted or funded. Within the past decade, changes in both the legal and social position of marijuana have opened the doors for people to freely access the incredible health benefits, and often times it is prescribed by their physicians.
CBD is popular among patients with a range of health issues, especially medical marijuana patients who don't wish to experience the psychoactive effects. More research is being done, but medical research suggests CBD can help treat many different health ailments.
Industrial hemp is a derivative of the cannabis plant that contains large amounts of CBD and low amounts of THC. CBD can be extracted from industrial hemp to make legal hemp oil, which has been the center of many recent research studies for its promising hemp CBD benefits. CBD products derived from industrial hemp plants contain less than 0.3% THC. Industrial hemp became federally legal for cultivation by state authorized institutions after the 2014 Farm Bill was signed. The updated 2018 Farm Bill will remove hemp from the DEA’s list of controlled substances which will also increase the exposure of potential medical CBD benefits.
THE ENDOCANNABINOID SYSTEM
CBD works by interacting with the body’s endocannabinoid system (ECS), which was discovered by Raphael Mechoulam about thirty years ago. When Dr. David Allen, a retired cardiac surgeon and cannabinoid research scientist, commented on his thoughts about the discovery of the ECS, he said, “The discovery of the endocannabinoid system is the single most important medical, scientific discovery ever. More people will be saved by manipulation of the endocannabinoid system than are currently saved by surgery.”
There is no denying that the ECS has been a remarkable discovery for humanity as it is the largest neurotransmitter system in the human body. The ECS contains receptors that regulate bodily functions such as mood, pain, memory, appetite, metabolism, bone development, sleep, and immune function. The receptors, which are categorized as CB1 and CB2, are activated by natural endocannabinoids produced by the human body as well as by plant cannabinoids.
HOW CBD WORKS
Cannabidiol does minimal binding with the CB1 and CB2 receptors, however, it regulates several non-cannabinoid receptors and ion channels located in the ECS to evoke potential CBD benefits. CBD also acts through several receptor-independent pathways—for instance, by prolonging the reuptake of endogenous neurotransmitters and by either boosting or reducing the binding of some G-protein coupled receptors.
Research suggests that CBD can directly activate the G-protein coupled, 5-HT1A serotonin receptor. This receptor is associated in a range of biological and neurological processes, such as anxiety, pain perception, sleep, appetite, nausea, and addiction. CBD also directly binds with ion channels such as TRPV1, a vanilloid receptor known to mediate pain, inflammation, and body temperature.
Other studies also indicate that CBD blocks another G-protein coupled receptor, GPR55. This receptor is also known as an “orphan receptor” because it is still unknown if it belongs to a larger family of receptors. GPR55 is present in the brain, and especially in the cerebellum. It is responsible for modulating physiological processes such as bone density and blood pressure. Osteoporosis, a bone disease that results in the body losing too much bone or producing too little bone, can be a direct effect of overactive GPR55 signaling. According to the study, GPR55 has also been seen in various cancer types. Because CBD acts as an antagonist for this receptor, it may act to decrease bone decay and cancer cell proliferation.
Research conducted exploring what is CBD and CBD benefits also concludes that cannabidiol produces an anti-cancer effect by activating PPARs, or peroxisome proliferator activated receptors. These receptors are located on the nucleus of cells. Activation of the PPAR-gamma receptor produces anti-proliferative effects and provokes tumor regression in human lung cell lines. PPAR-gamma activation also degrades amyloid-beta plaque, which plays a crucial role in the development of Alzheimer’s disease. PPAR receptors are also known to regulate genes partaking in energy homeostasis, lipid uptake, insulin sensitivity, as well as other metabolic functions.
TO USE CBD
Cannabidiol can be taken in different forms to suit the preference and needs
of its users. People seeking CBD oil benefits have a wide selection of options
to choose from our premium quality product line.
Tinctures are the original way to take CBD oil. They are made by combining CBD with natural hemp oil. The healthy fats found in these mixes allow the body to better process the cannabidiol, optimizing CBD oil benefits. Tinctures are an easy way to consume CBD oil as the oil is placed underneath the tongue using a dropper. It is then held there for at least 10 seconds before ingesting. Using the dropper, you can take the CBD oil pure or can mix it with your favorite food or beverage.
Not everybody that consumes or uses cannabidiol has a health condition. Edibles such as CBD gummies are popular for preventative care. However, they are also frequently used by people with mild anxiety, stress, and sleeping disorders. They are definitely the most delicious way to consume CBD, and probably the easiest as well. Consumers love that they can get all hemp CBD benefits in the tastiest way possible.
CBD does not necessarily have to be consumed orally. Due to technological advancements and further research done on hemp CBD benefits, products are now available that are made specifically for external use. CBD topical creams are specially formulated for treating specific areas of the body with pain and inflammation.
Vaporizing is an effective way to use cannabidiol for CBD benefits, as it delivers almost instant effects and it tends to be safer and cleaner than smoking cigarettes and vaping. Our CBD cartridges provide different “mood” effects and are ideal for people that want an alternative to the harsh chemicals found in tobacco and nicotine products.